DEFENSIL^®-SOFT contains an extract obtained from Albatrellus confluens. It acts as a neuro- soother by extending the feel- good zone of stressed and irritated skin.

Our bodies are exposed to irritants and stressors on a daily basis. How we deal with these depends on our own individual nervous system. But there is one thing common to us all: when we are under too much stress we end up off balance. The same applies to our skin. There is no other organ in our body that reacts so extensively to stress and the skin has an active sensory system in which the neurons are the most important players. Our skin becomes sensitive if its nerve cells are constantly in the firing line or inflammatory reactions persist – itching and irritation are the results. Key player for these sensations is the TRPV1 receptor. It is a calcium channel that is designed to open following stimulation by heat, acids or chemical compounds that act as irritants. TRPV1 is located in the cell wall of sensory neurons.

Clinical studies have shown that DEFENSIL^®-SOFT instantly soothes irritated skin and prevents the development of sensitive skin after irritation in just a few minutes. It extends the skin’s feel-good zone by augmenting the pain threshold and reducing the perception of the stinging and burning effects that occur, for example, in association with sunburned skin. DEFENSIL^®-SOFT rapidly suppresses skin microcirculation and skin reddening.

In-vitro studies have demonstrated the direct inhibition of the neuronal pain receptor TRPV1 and prevention of its sensitisation. As a consequence, the calcium influx into this neuron and the release of CGRP is blocked, thus calming sensations and epidermal tissue. The neurogenic inflammatory reaction is almost completely suppressed.

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